Chelidonine Powder
Description
Premium Chelidonine Powder – Pure Isoquinoline Alkaloid Extract for Research & Formulation
Hunan Clover Origins Biotech Co., Ltd. is a manufacturer of Chelidonine Powder which is pharmaceutical grade and is extracted from Macleaya cordata fruit pods. Our standardized extract is 98% pure, validated by HPLC, and has an annual production capacity of more than 5,000 tonnes in three ISO certified facilities. With over 25 years of experience in botanical extracts , we supply this bioactive isoquinoline alkaloid with rigorous heavy metals testing (<10ppm), pesticide residues to EU levels and full batch traceability.
Each batch undergoes third party (Eurofins and SGS) testing. We use cutting-edge extraction with ethanol-water that retains the native alkaloid profile and leaves solvent residues at <50ppm.
If you are creating veterinary formulations, herbal antibacterial treatments, or research chemicals, our product provides consistent quality, with flexible MOQ options and fast 5-10 day bespoke production schedules.
What Is Chelidonine Powder?
Chelidonine is a naturally occurring isoquinoline alkaloid found mostly in the fruit pods of Macleaya cordata (Plume Poppy). It is also present in Chelidonium majus (greater celandine).
This bioactive molecule has been of great interest in phytochemical studies. Its unique molecular framework is responsible for several biological processes explored in laboratory conditions.
When compared to synthetic chelidonine, plant-derived chelidonine retains a complex phytochemical matrix. Its natural origin makes it useful for traditional herbal preparation and research applications.
Our sourcing approach is based on sustainable harvesting of Macleaya cordata in China. We extract with ethanol-water and purify chromatographically to obtain 98% active content.
Technical Specifications
| Parameter | Specification |
|---|---|
| Active Ingredient | Chelidonine ≥98% |
| Test Method | HPLC |
| Botanical Source | Macleaya cordata (Willd.) R. Br. |
| Plant Part Used | Fruit Pod |
| Appearance | Yellow Fine Powder |
| Extraction Solvent | Ethanol & Water |
| Particle Size | 95% through 80 mesh |
| Loss on Drying | ≤5.0% |
| Heavy Metals | <10ppm |
| Lead (Pb) | <2ppm |
| Arsenic (As) | <1ppm |
| Pesticide Residues | Compliant with EU standards |
| Total Plate Count | <1,000 CFU/g |
| Yeast & Mold | <100 CFU/g |
| Shelf Life | 24 months (sealed, cool, dry) |
| Storage | Store in airtight containers away from light |
Core Applications & Research Directions
Veterinary and Animal Health Products
Laboratory investigations have shown that chelidonine has antibacterial effects. This is useful for research on feed additives and formulations for animal wellbeing. It is used by many veterinary providers in natural health programs.
Herbal Anti-Microbial Agents
Macleaya cordata extracts have been used in traditional herbal medicine systems for a long time. Modern formulators employ standardized Chelidonine Powder to make uniform herbal mixes with recorded alkaloid concentration.
Pain & Inflammation Studies
Preliminary laboratory tests indicate possible anti-inflammatory and modest analgesic effects. Chelidonine is a useful study tool for scientists researching synthetic chemical alternatives in plants.
Research in Bioactive Agriculture
Its natural antibacterial and antispasmodic characteristics make it attractive to agricultural experts. Research investigates its use as a possible botanical pesticide replacement or plant growth regulator.
Hepatobiliary Support Studies
Modern study has been sparked by traditional use in liver support. In the laboratories, scientists study the mechanics of bile flow and the protection of liver cells in a controlled environment.
Key Benefits & Biological Activities
Antimicrobial Action
Laboratory studies show activity against various bacterial and fungal strains. This makes chelidonine interesting for natural preservative research and infection control studies.
Anti-Inflammatory Potential
In vitro research indicates it may help modulate inflammatory pathways. This property supports its investigation in chronic inflammation research models.
Antispasmodic Properties
Studies suggest potential smooth muscle relaxation effects. This has implications for digestive health research and gastrointestinal formulation development.
Analgesic Research
While milder than pharmaceutical analgesics, chelidonine shows promise in irritation-related discomfort studies. It's particularly relevant for topical and herbal pain relief research.
Liver Function Support
Traditional hepatoprotective use is now being validated through modern research. Studies examine its effects on liver enzyme levels and bile secretion in animal models.
Manufacturing Excellence & Quality Control
Our three GMP-certified facilities operate under FDA registration and FSSC 22000 standards. Each production batch undergoes 18-point quality testing before release.
Advanced Extraction Process
We use a proprietary ethanol-water extraction system that maximizes alkaloid recovery. Counter-current extraction technology ensures consistent 98% purity without harsh chemical solvents.
Contamination Control
Heavy metal testing uses ICP-MS technology. Pesticide screening covers 500+ compounds following EU and USDA organic guidelines. Microbial testing follows USP standards.
Third-Party Verification
Every commercial batch includes Eurofins or SGS testing reports. We provide Certificates of Analysis (COA) with complete phytochemical profiles and contaminant screening data.
Traceability System
From raw material sourcing to final packaging, every step is documented. Batch codes link to harvest location, extraction date, and all quality test results.
Our rapid response system delivers technical documents within 12 hours. Sample shipments leave our facility within 1-2 days for stock items.
Packaging & Storage Recommendations
Standard Packaging Options
- 1kg aluminum foil bag
- 5kg aluminum foil bag inside carton
- 25kg fiber drum with double food-grade poly bags
- Custom packaging available for OEM/ODM partners
Storage Conditions
Store in sealed containers in a cool, dry environment below 25°C. Protect from direct sunlight and moisture. Avoid prolonged exposure to air.
Shelf Life
24 months when stored properly in original sealed packaging. We recommend using within 18 months after opening for optimal potency.
Handling Precautions
Use appropriate PPE when handling concentrated alkaloid powders. Avoid inhalation of fine particles. Work in well-ventilated areas.
FAQ
Q: What makes your product different from the regular Macleaya cordata extracts?
A: Most macleaya extracts are standardized to total alkaloids (typically 60%). Our product is precisely purified to 98% purity of chelidonine by employing sophisticated chromatography. This enables investigators to work with a near-pure substance, instead of a mixed alkaloid extract, which gives better control over the formulation.
Q: Can this substance be used in dietary supplements?
A: Regulatory status depends on the region. In several markets, chelidonine is regarded as a research chemical or a botanical constituent for traditional use. We suggest consulting with regulatory specialists in your target market. We have all the documentation you need to help you through the compliance procedure.
Q: Is the product soluble in water?
A: Chelidonine is a pure alkaloid and has low solubility in water (~0.5mg/mL at ambient temperature). It dissolves more easily in slightly acidic solutions or in alcohol and water combinations. For aqueous formulations we suggest solubilizers or cyclodextrin complexation.
Q: What's your minimum order quantity (MOQ)?
A: The MOQ is 1kg for stock specs (98% chelidonine) as standard. We may offer flexible terms to research organisations and we have smaller (50-100g) samples for initial testing. MOQs for custom specs may vary depending on production requirements.
Q: Do you offer bespoke extraction ratios or different purity?
A: Yes. Our R&D team can produce unique specs from 50%-98% purity. We also provide complete alkaloid extracts with determined amount of chelidonine. Usually, it takes 7-10 days to develop a custom formulation and a sample can be sent within 7 working days.
Q: What documentation do you send with the product?
A: We include a Certificate of Analysis (COA), MSDS, allergen statement, BSE/TSE declaration, non-GMO statement and certifications (Kosher, Halal, ISO) with each order. Additional regulatory documentation is available for customs clearance.
Q: How stable is the powder in transport and storage?
A: Chelidonine alkaloids are stable for 24 months if properly packaged and stored. We employ moisture barrier packaging, and can add desiccants for delivery to humid locations. Short exposure to temperature variations during shipment has little effect.
Q: Can you help with analytical method development?
A: Yes. Our technical team can assist with method transfer and provides HPLC method procedures. We provide analytical testing services and can validate techniques for your unique application in 5-7 business days.
Partner With a Trusted Biotech Leader
Ready to source premium Chelidonine Powder for your next project? Contact us today at info@cloverorigins.com for quotations, COA samples, or technical specifications.
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